{"id":41,"date":"2021-08-06T18:35:17","date_gmt":"2021-08-06T18:35:17","guid":{"rendered":"https:\/\/www.explant.nl\/?page_id=41"},"modified":"2021-08-10T15:59:14","modified_gmt":"2021-08-10T15:59:14","slug":"isolation-natural-products","status":"publish","type":"page","link":"https:\/\/www.explant.nl\/index.php\/services-2\/isolation-natural-products\/","title":{"rendered":"ISOLATION OF NATURAL PRODUCTS"},"content":{"rendered":"\n
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Examples of metabolites isolated from plants or generated through biosynthesis and\/or<\/span><\/strong><\/p>\n\n\n\n

bioconversion by plant cell cultures<\/span><\/strong><\/p>\n\n\n\n

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Pyrrolizidine alkaloids:<\/strong><\/p>\n\n\n\n

Supported by funding in two MIT collaboration projects, methods were developed for purification of pyrrolizidine alkaloids from Jacobaea <\/em>sp. for ecological and toxicitiy studies. Available on order are: senecionine, seneciphylline, jacobine, erucifoline, acetylseneciphylline, acetylerucifoline, jaconine and jacoline, including their respective N-oxides, at high purity levels.<\/p>\n\n\n\n

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Strictosidine:<\/span><\/strong><\/p>\n\n\n\n

Supported by funding in an IOP genomics project, Catharanthus roseus <\/em>cell-lines were optimized for strictosidine production. With support of an IPC project, methods were subsequently developed  for isolation of strictosidine and conversion to strictosamide, a potential anti-malarial drug, currently extracted from Nauclea latifolia <\/em>trees.<\/span><\/p>\n\n\n\n

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Gluco-vanilline and Gluco-vanillylalcohol:<\/span><\/strong><\/p>\n\n\n\n

As follow-up of the RAAK Hollandse Vanille project, ExPlant developed methods to produce gluco-vanilline and gluco-vanillylalcohol from vanillin by biotransformation by Catharanthus<\/em> cultured cells. The new glycosylated products have been isolated by prep-HPLC at a purity > 97%.<\/span><\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n

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<\/p>\n","protected":false},"excerpt":{"rendered":"

Examples of metabolites isolated from plants or generated through biosynthesis and\/or bioconversion by plant cell cultures Pyrrolizidine alkaloids: Supported by funding in two MIT collaboration projects, methods were developed for purification of pyrrolizidine alkaloids from Jacobaea sp. for ecological and toxicitiy studies. Available on order are: senecionine, seneciphylline, jacobine, erucifoline, acetylseneciphylline, acetylerucifoline, jaconine and jacoline, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":98,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-41","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.explant.nl\/index.php\/wp-json\/wp\/v2\/pages\/41","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.explant.nl\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.explant.nl\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.explant.nl\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.explant.nl\/index.php\/wp-json\/wp\/v2\/comments?post=41"}],"version-history":[{"count":12,"href":"https:\/\/www.explant.nl\/index.php\/wp-json\/wp\/v2\/pages\/41\/revisions"}],"predecessor-version":[{"id":297,"href":"https:\/\/www.explant.nl\/index.php\/wp-json\/wp\/v2\/pages\/41\/revisions\/297"}],"up":[{"embeddable":true,"href":"https:\/\/www.explant.nl\/index.php\/wp-json\/wp\/v2\/pages\/98"}],"wp:attachment":[{"href":"https:\/\/www.explant.nl\/index.php\/wp-json\/wp\/v2\/media?parent=41"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}